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Hyperglycaemia and foetal malformation: The higher than normal rate of congenital abnormalities among infants of diabetic mothers is well known and previous work has correlated teratogenesis with levels of hyperglycaemia. In another study recently performed by Sheffield et al in the USA, 2277 subjects (1.6% of 145 196) were screened for gestational diabetes over a period of 10 years. Some 10% had fasting hyperglycaemia and 0.3% had pre-gestational diabetes. Infant malformations were observed in 1.5% of non-diabetics, in 1.2% of those with gestational diabetes and normal fasting glucose, in 4.8% with gestational diabetes plus fasting hyperglycaemia, and in 6.17% of those with established pre-gestational diabetes. Read more: Obstet Gynecol 2002;100:925-30 |